Case report: Regression of Glioblastoma after flavivirus infection

Case report: Regression of Glioblastoma after flavivirus infection

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Glioblastoma is the most frequent and aggressive primary brain cancer.In preclinical here studies, Zika virus, a flavivirus that triggers the death of glioblastoma stem-like cells.However, the flavivirus oncolytic activity has not been demonstrated in human patients.Here we report a glioblastoma patient who received the standard of care therapy, including surgical resection, radiotherapy and temozolomide.

However, shortly after the tumor mass read more resection, the patient was clinically diagnosed with a typical arbovirus-like infection, during a Zika virus outbreak in Brazil.Following the infection resolution, the glioblastoma regressed, and no recurrence was observed.This clinical response continues 6 years after the glioblastoma initial diagnosis.